Improved removal performance of large medium-sized molecules
The FDY-series was developed for applications that require an extended sieving coefficient profile.
With these dialyzers, removal of low-molecular-weight proteins and middle to large-molecular weight substance is high.
Dialyzers for removing molecules larger than β2MG
🔹 Optional endotoxin-retentive performance
🔹 No PVP elution
🔹 Optimal follow fibers design
Optional endotoxin-retentive performance
Polyester polymer alloy (PEPA) membrane is synthetic polymer membrane and consists of two polymers –polyethersulfone (PES) and polyarylate (PAR).
PEPA membrane utilizes a polymer blend technology and creates a multicomponent polymer with strong points of each polymer.
The specially developed asymmetric 3-layer structure of the PEPA® – membrane provides protection against endotoxins and their fragments.
Specially developed 3-layer structure of the PEPA membrane
[1] Dialysate side: skin layer; endotoxin block
[2] Main body: porous layer; mechanical strength
[3] Blood side: skin layer; solute separation
No PVP elution
In FD series, the appropriate pore size of PEPA® membrane can be controlled easily by a mixture ratio of two polymers, so the use of a hydrophilizing agent is low as necessary for hydrophilization purpose only.
With this optimum hydrophilization technology, there is no PVP elution in the FD series.
Optimal follow fibers design
The optimized inner diameter of the follow fibers ensures a low blood side pressure drop,
and the membrane thickness of 30 μm provides good diffusion properties.
NIKKISO original PEPA®-membrane
| Membrane thickness | 30μm |
| Hollow fiber inner diameter | 210μm |
| Membrane material | PEPA(Polyester - Polymer alloy) |
| Housing material | Polycarbonate |
| Sealant material | Polyurethane |
| Sterilization | Gamma rays |
PEPA Dialyzer FDY
| Model | Surface area [㎡] | Volume [mL] | UFR*1 [mL/hr/mmHg] | Clearance[mL/min]*2 | ||||
|---|---|---|---|---|---|---|---|---|
| Urea | Creatinine | Phosphate | VitaminB12 | |||||
| FDY-10 | 1.0 | 61 | 37 | 180 | 170 | 155 | 113 | |
| FDY-12 | 1.2 | 74 | 48 | 186 | 177 | 168 | 126 | |
| FDY-15 | 1.5 | 92 | 54 | 191 | 183 | 178 | 137 | |
| FDY-18 | 1.8 | 111 | 59 | 193 | 186 | 182 | 144 | |
| FDY-21 | 2.1 | 129 | 64 | 194 | 187 | 183 | 148 | |
*1. QB 200mL/min, TMP 50mmHg with bovine blood (Ht: 32%, TP: 6.0g/dL) (ISO8637-1:2017)
*2. QB 200mL/min, QD 500mL/min, QF 0mL/min(ISO8637-1:2017)
Reference
1. M.Hayama, et al., Optimum dialysis membrane for endotoxin blocking., J. Membr. Sci., 219 (2003), 15-25
2. Yamashita, A. et al. Blood compatibility and filtration characteristics of a newly developed polyester polymer alloy membrane. Hemodial. Int.8 (4), 368-371, 2004
3. Yamazaki, K. et al. Nanoscale analysis of hydrophilicity-hydrophobicity distribution on inner surfaces of wet dialysis membrane by atomic force microscopy. J Membr Sci 396: 38-42, 2012
Disclaimer:
* Product appearance and specifications are subject to change without prior notice.
* Photographs of the product may appear differently due to variations in printing or display conditions.
* Specifications may vary depending on local regulations and registration status. Please contact your local distributor for details.
* Always read the accompanying operation manual before use.
